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One hypothesis relates to the high mutation rate seen within melanomas compared with other tumor types.12 A recent study investigating the mutational landscape in melanoma found a median of 171 mutations in melanomas of sun exposed regions compared with nine mutations in sun shielded regions.13 This compares to approximately 80 mutations in an average colon or breast tumor.14 The majority of these mutations are passenger mutations that are non essential for the survival of the tumor but offer an opportunity for immune recognition.

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Thus, the proposed definition for NERD by Fass et al.6 is the presence of typical symptoms of GERD owing to intraesophageal reflux in the absence of visible esophageal mucosal injury on endoscopy. La mayora de los futbolistas de Nueva Zelanda juegan en la liga domstica, entre ellos su delantero Shane Smeltz (Perth).

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